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Aims: We aimed to assess and characterize sex differences in adverse drug reactions ADRs reported to the national pharmacovigilance centre in the Netherlands while considering differences in drug use. Methods: ADRs spontaneously reported by healthcare professionals and patients to the Netherlands pharmacovigilance centre Lareb were used.

Data about the of drug users was obtained from the National Health Care Institute. Sex-specific ADRs, like gynaecological problems, were excluded. Sex differences in specific drug-ADR combinations were tested using bivariate logistic regression analyses in which the of drug users per sex was taken into . : In total, drug-ADR combinations were analysed.

Most of these drug-ADR combinations were reported more often for women combinations. Drugs with the highest of ADRs that were more often reported for women included thyroid hormones 32 combinations and antidepressants 16 combinations for the centrally acting sympathomimetics; 14 combinations for other antidepressants.

Some ADRs were predominantly reported for women across a range of drugs such as headache and dizziness whereas other ADRs such as tendon ruptures and aggression were reported more often for men. Conclusions: Identified sex differences in reported ADRs often referred to women. These differences may have various causes, including pharmacological and behavioural causes, which need to be further assessed. The may ultimately lead to sex-specific prescribing or monitoring recommendations.

Keywords: drug-related side effects and adverse reactions; gender; pharmacovigilance; precision medicine; sex. The authors have no competing interests to declare. Flowchart of the of drug—adverse drug reaction ADR combinations. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search. Advanced Clipboard. Display options Display options. Create file Cancel. citation Subject: 1 selected item: - PubMed. Format: Summary Summary text Abstract Abstract text. MeSH and other data. Send Cancel.

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Full text links Cite Display options Display options. Abstract Aims: We aimed to assess and characterize sex differences in adverse drug reactions ADRs reported to the national pharmacovigilance centre in the Netherlands while considering differences in drug use.

Conflict of interest statement The authors have no competing interests to declare. Figures Figure 1 Flowchart of the of…. Figure 1 Flowchart of the of drug—adverse drug reaction ADR combinations. Figure 4 Overview of of combinations…. The full list is presented in Figure S1. Figure 5 Overview of of combinations…. The full list is presented in Figure S3. See this image and copyright information in PMC. Similar articles Influence of age, sex and seriousness on reporting of adverse drug reactions in Sweden. Holm L, et al.

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Sex Differences in Reported Adverse Drug Reactions of Selective Serotonin Reuptake Inhibitors